New York, US – July 15, 2019 Single domain antibody (other names: nanobody, domain antibody, VHH, VNAR or sdAb) is a kind of antibody fragment made up of a single monomeric variable antibody domain and lacking in the light chain and CH domain of the heavy chain in conventional Fab region. Creative Biolabs spent more than a decade on the services and technologies in the field of single domain antibody that possesses the features of high stability, outstanding penetrability and research potentiality, which cover Single Domain Antibody Library Construction and Screening, Intrabody Discovery, Premade Single Domain Antibody Library Screening, and Bispecific Single Domain Antibody Production, etc.
Sub-sectors of sdAb library construction and screening services include
1. Construction of immunized sdAb library
Under the assistance of the up-to-date phage display technology and profound professional knowledge, Creative Biolabs is capable of constructing VHH or VNAR based single domain antibody libraries through immunized camel, llama, alpaca or shark. By reverse transcription and polymerase chain reaction, a library of single domain antibodies containing 10-100 million clones is regularly produced.
2. Construction of synthetic sdAb library
It’s possible to construct synthetic naive single domain antibody libraries with the help of Creative Biolabs. The designed camelized human sdAb libraries that are based upon the monomerization of human antibody heavy chain framework are good sources opposing self, non-immunogenic, and toxic antigens.
3. Screening of single domain antibody libraries
The first-level screening services are offered to assist clients in making selection of the high-affinity, specific sdAbs by isolating single domain antibody inhibitors and heat denaturation on phage surface.
4. Large-scale production of recombinant sdAb
Plant scale production platforms established by Creative Biolabs guarantee all the orders delivered on time.
To meet the requirements specifically according to global clients on single domain antibody, Creative Biolabs has combined the abreast of the times techniques with advanced phage display technology to offer a variety of services including sdAb library construction, screening, and sdAb production with the help of knowledgeable and faithful scientists expert in tailoring the most appropriate protocol to develop high-quality single domain antibodies for customers’ research purposes. Details and instructions correspondingly can be reached at https://www.creative-biolabs.com/.
About Creative Biolabs
Creative Biolabs, founded by a group of experts, is the leading custom service provider possessing extensive experience with over 10 years history in the field of various antibody production and engineering with service portfolio that includes mouse and rat monoclonal antibody production using hybridoma technology, human, monkey, rabbit, chicken, dog, llama and camel monoclonal antibody production using various antibody library technologies (including phage display, bacterial display and yeast display).
Company Name: Creative Biolabs
Contact Person: Candy Swift
Email: Send Email
Address:45-1 Ramsey Road
State: New York
Country: United States