IntegrateRNA Develops One-stop Solutions for Oligonucleotide Conjugation Services to Facilitate Diagnostic and Targeted Drug Delivery

November 17 01:12 2021
IntegrateRNA announced the release of its one-stop solutions for oligonucleotide conjugation services to facilitate research in the field of targeted drug delivery.

New York, USA – November 16, 2021 – IntegrateRNA, the division of Creative Biogene, is the global provider developing complete solutions for RNA discovery, expression analysis, functional research and mechanism analysis. With unique technologies and satisfactory services, IntegrateRNA is dedicated to enabling researchers to better understand human diseases and promote the development of the RNA research field. Recently, IntegrateRNA announced the release of its one-stop solutions for oligonucleotide conjugation services to facilitate research in the field of targeted drug delivery.

IntegrateRNA utilizes chemical coupling methods to link functional ligands to oligonucleotides including siRNA, ASO, miRNA, to optimize the stability, cellular uptake and pharmacokinetic characteristics of therapeutic oligonucleotides, providing high-quality oligonucleotides coupled with GalNAc, PEG, cholesterol, peptides, antibodies, proteins, aptamers or dye labels to facilitate diagnosis and targeted drug delivery. All oligonucleotide conjugates are produced under strict quality control and quality assurance procedures to ensure complete customer satisfaction.

IntegrateRNA provides customized folic acid-oligonucleotide conjugation, including folate-siRNA, folate-ASO, and folate-microRNA. Different covalent binding methods can be used to bind folic acid to the 3′-end or 5′-end of the oligonucleotide to improve the targeted delivery of therapeutic oligonucleotides. With a one-stop solution, including oligonucleotide synthesis, modification and coupling, IntegrateRNA ensures the flexibility of coupling chemistry, which is designed according to the characteristics of the target biopolymer and the customer’s intended use. The final result also follows a strict QC process: delivery of COA, MS, HPLC and/or other analytical data of the final product.

In addition, based on expertise in synthesis, bioconjugation and purification, IntegrateRNA provides customized antibody-oligonucleotide conjugates (AOC) for global customers, and has developed a method for linking oligonucleotides to target antibodies through terminal functional groups. In order to provide high-quality conjugates for customer applications and maximize performance, IntegrateRNA provides a variety of options for AOC purification and characterization, including analytical size exclusion chromatography, PAGE gel analysis, mass spectrometry, and RP-HPLC and LC-MS.

IntegrateRNA has highly skilled scientists dedicated to biological coupling and cross-linking technology, providing coupling services, combining oligonucleotides with proteins, including fluorescent proteins, carrier proteins and enzymes. The experienced technical team can help customers produce high-quality oligoprotein conjugates and flexibly adapt to special requirements.

“IntegrateRNA provides you with reliable and professional RNA-related services and products. We are committed to meeting customer needs at reasonable prices and providing quality products and services.” said Marcia Brady, the marketing director of Creative Biogene, she also added, “IntegrateRNA has successfully completed a variety of different types of RNA discovery, synthesis, for specific requirements, we can also provide customized solutions to promote the research development.”

About IntegrateRNA

IntegrateRNA, as the division of Creative Biogene that holds a leading position in providing complete solutions for RNA research, has years of experience in next-generation sequencing and develops microarray platforms that enable researchers to explore the world of RNA on an unprecedented scale, and mapping all RNAs involved in cell life programs, human diseases, and drug discovery.

Media Contact
Company Name: Creative Biogene
Contact Person: Marcia Brady
Email: Send Email
Phone: 1-631-386-8241
Country: United States
Website: https://integraterna.creative-biogene.com

view more articles

About Article Author